Peyronie's Disease: Symptoms, Causes, and Treatment – Dr. Tepeler

Peyronie's disease is a relatively common condition that affects the penis, causing a curve or bend during erections. It is characterized by the deposition of scar tissue in the tunica albuginea, a tough fibroelastic tissue that surrounds the erectile bodies of the penis. This scar tissue can lead to various symptoms, including pain, plaque formation, and erectile dysfunction. In this comprehensive guide, we will delve into the symptoms, causes, and treatment options for Peyronie's disease.

Peyronie's Disease


Understanding Peyronie's Disease

Peyronie's disease is a connective tissue disorder that affects the penis. It shares similarities with Dupuytren's contracture, a condition that affects the hands. The disease is characterized by a triad of symptoms: bent erections, penile plaque, and pain during erections. Despite its prevalence, Peyronie's disease remains relatively unknown to the public.

The penis is composed of three cylinders: the paired erectile bodies (corpora cavernosa) and the urethra. During an erection, blood fills the sinusoidal tissue within the erectile bodies, causing the penis to become erect. The outer covering of the erectile bodies, known as the tunica albuginea, is responsible for the shape and size of the erection.

In Peyronie's disease, scar tissue deposits form within the tunica albuginea. This scar tissue does not stretch as well as normal tissue, leading to the characteristic curvature of the penis. The scar tissue is primarily composed of collagen, which can harden and become as thick as bone in severe cases. This deposition of scar tissue is responsible for the various symptoms associated with Peyronie's disease.

Symptoms of Peyronie's Disease

The primary symptom of Peyronie's disease is a noticeable curve or bend in the penis during erections. The direction of the curve may vary, including upward, downward, or sideways bends. Other common symptoms include palpable penile plaque, which can be felt under the skin, and pain during erections. Men with Peyronie's disease may also experience softer erections, difficulty maintaining an erection, and lumps in the penis.

The severity of symptoms can vary from person to person. In some cases, the curvature may be mild and have minimal impact on sexual function. However, more severe cases can result in significant pain, difficulty with intercourse, and emotional distress.

Causes of Peyronie's Disease

The exact cause of Peyronie's disease is not fully understood, but several factors may contribute to its development. Trauma to the penis is believed to play a role, although the trauma can be both acute (such as a penile fracture) or chronic (repeated trauma during sexual intercourse). It is important to note that not all men who experience penile trauma develop Peyronie's disease, suggesting that additional genetic or environmental factors may be involved.

There is evidence to suggest a genetic predisposition to Peyronie's disease, with a positive family history often observed. Additionally, an association has been found between Peyronie's disease and other connective tissue disorders, such as Dupuytren's contracture. Certain health conditions, including diabetes and autoimmune diseases, have also been linked to an increased risk of developing Peyronie's disease.

Diagnosing Peyronie's Disease

Diagnosing Peyronie's disease typically involves a physical examination and a discussion of symptoms. During the examination, a healthcare professional will assess the location and extent of scar tissue by palpating the penis. They may also measure the length of the penis and inquire about any pain or difficulties experienced during erections.

In some cases, additional tests may be recommended to confirm the diagnosis or rule out other conditions. Ultrasound imaging, often performed when the penis is erect, can provide detailed images of the plaques, blood flow, and any other irregularities. This imaging technique is commonly used to assess Peyronie's disease and guide treatment decisions.

Treatment Options for Peyronie's Disease

The management of Peyronie's disease depends on the stage of the condition, the severity of symptoms, and the impact on sexual function. Treatment options can be divided into non-surgical approaches and surgical interventions.

Non-Surgical Treatments

During the acute phase of Peyronie's disease, when symptoms are worsening, non-surgical treatments are typically recommended. These treatments aim to reduce pain, slow disease progression, and improve sexual function. Some of the non-surgical options include:

Traction Therapy: This involves using a device that stretches the penis to promote straightening and reduce curvature. Traction therapy may be particularly effective when used early in the disease process.


Medications: Certain medications, such as verapamil and collagenase, have shown promise in treating Peyronie's disease. These medications can be injected directly into the plaque to help break it down and reduce curvature.


Penile Injections: Various substances, including verapamil and interferon, can be injected into the plaque to soften the scar tissue and improve symptoms.

Oral Medications: Some oral medications, such as vitamin E and potassium aminobenzoate, have been used in the treatment of Peyronie's disease. However, their effectiveness is not well-established, and they are not commonly recommended.

Surgical Options

If non-surgical treatments do not provide sufficient relief or if the disease has stabilized, surgical intervention may be considered. Surgical options aim to correct the curvature, improve sexual function, and address any associated penile deformities. The specific surgical procedure recommended will depend on the severity and location of the curvature, as well as individual patient factors. Common surgical options include:

Penile Plication: This procedure involves suturing the unaffected side of the penis to reduce curvature and straighten the penis. It is typically recommended for mild-to-moderate curvature and does not result in significant penile shortening.


Incision or Excision and Grafting: In more severe cases, surgical techniques involving incisions or excisions of the plaque may be necessary. These procedures allow for the straightening of the penis and may involve the use of grafts to cover any defects.


Penile Implants: For men with Peyronie's disease and concurrent erectile dysfunction, penile implants may be considered. These devices are surgically inserted into the penis to provide rigidity and improve sexual function.

It is important to note that surgical interventions carry potential risks and complications, including penile shortening, numbness, and worsening erectile dysfunction. Therefore, careful consideration and thorough discussion with a healthcare professional are essential when considering surgical options.

Preventing Peyronie's Disease

While it may not be possible to prevent Peyronie's disease entirely, certain measures may help reduce the risk or severity of the condition. These include:

·         Safe Sexual Practices: Engaging in sexual activities with caution and avoiding traumatic injuries to the penis can minimize the risk of developing Peyronie's disease.

·         Maintaining Good Overall Health: Managing underlying health conditions, such as diabetes and high blood pressure, may help reduce the risk of developing Peyronie's disease.

·         Avoiding Smoking: Smoking has been associated with an increased risk of developing Peyronie's disease. Quitting smoking can have numerous health benefits, including reducing the risk of developing this condition.

Support and Coping Strategies

Living with Peyronie's disease can have a significant impact on mental and emotional well-being. Many individuals experience stress, depression, and body image concerns due to the physical changes caused by the disease. Seeking support and implementing coping strategies can help individuals navigate the challenges associated with Peyronie's disease. Some strategies to consider include:

·         Open Communication: Talking to a partner about the condition can help foster understanding and support.

·         Professional Counseling: Consulting with a mental health professional who specializes in sexual health can provide guidance and support during this challenging time.

·         Self-Care: Engaging in self-care activities, such as exercise, meditation, and hobbies, can help reduce stress and improve overall well-being.

·         Peer Support: Connecting with others who have Peyronie's disease through support groups or online communities can provide a sense of belonging and offer valuable advice and support.


Peyronie's disease is a relatively common condition that can significantly impact a person's sexual and emotional well-being. Understanding the symptoms, causes, and treatment options for Peyronie's disease is essential for individuals affected by the condition. By seeking medical advice, exploring available treatment options, and implementing coping strategies, individuals with Peyronie's disease can improve their quality of life and manage the challenges associated with the condition. If you suspect you may have Peyronie's disease or are experiencing symptoms, it is important to consult with a qualified healthcare professional for an accurate diagnosis and appropriate treatment plan.

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